Passienol™ is the polyphenol derived from the passion fruit seed that Morinaga successfully developed as a result of its extensive research. It has a high concentrate of the polyphenol piceantannol and its dimer scirpusin. Morinaga was the first in the world to discover that the passion fruit seed is a great source of piceantannol, and the company was able to extract it in a highly concentrated formula. We are excited about the anti-aging qualities that are associated with Passienol™.
Benifuuki is a brand of tea that was jointly developed by the National Agriculture and Food Research Foundation and Institute of Vegetable and Tea Science (formerly a division of the Ministry of Agriculture, Forestry and Fisheries) and formally named. Formally named and registered in 1993, it has a very high content of methyl catechin, which is not often found in other types of tea and is highly resistant to disease and pests.
Through joint research with Morinaga & Co., Ltd., the Institute of Vegetable and Tea Science, and Kyushu University, it was discovered that the methyl catechin has a much higher absorption rate and higher antihistaminic qualities when compared to EGCG, the most common antihistamine in tea.
Based on SRI data released in January, 2015, Morinaga has the biggest share of the domestic cocoa market.
Cocoa is not only delicious, it has health benefits that are quickly gaining attention. Morinaga has been focusing its research efforts on the following characteristics of cocoa: it destroys helicobacter pylori; it helps alleviate sensitivity to cold; it has anti-flu virus effects; and it even fights periodontal disease. In joint studies with university-affiliated hospitals and nursing care facilities, cocoa has been implemented as part of a daily dietary supplement.
Some of the positive effects that have been observed with the use of cocoa as a daily dietary supplement include faster injury healing; improved digestion; faster recovery of zinc levels in patients recovering from sudden illnesses; anti-aging effects on FGP (Mato) brain cells; suppressed reaction to LPS, which are known to cause sepsis; and decreased sensitivity to cold.
The amount of protein included in our EMR (enzymatically modified rutin) is based on our research of efficient body development.
It is a well-known fact that the active oxygen produced after physical activity not only promotes damage to muscles, but also hinders the recovery process. Through joint research with a university, we have discovered that when consumed with protein, high absorption antioxidant EMR can stimulate muscle hypertrophy. Not only does EMR reduce the amount of muscle damage, it enhances the release of hormones that work in muscle synthesis.
We continue to pursue this line of research in our belief that EMR can play an integral part in promoting a healthy lifestyle not only for athletes but people of all ages and gender.
Food Allergen Testing
As a result of the recent increase in global interest in food allergies, regulations for the labeling of foods that contain allergens have been coming into effect in Japan since April 2001. Twenty-seven items have been designated for labeling and the Food Sanitation Act mandates that seven of those items (eggs, milk, wheat, buckwheat, peanut, shrimp, and crab) be listed in the ingredients.
We used our exclusive immunoassay technology to begin selling ELISA kits for allergen testing (five items) before the rest of the world in April 2002, and the kits were designated as official testing methods by the Japanese Ministry of Health, Labor, and Welfare in November of the same year. In 2005, Morinaga began selling FASPEK testing kits that allow users to measure allergen quantities in processed foods using an extract developed exclusively by the Morinaga Institute of Biological Science (MIoBS). That same year, the kits were designated as validated and accurate test kits by the Ministry of Health, Labor, and Welfare, and many Japanese public testing agencies, analysis agencies, and food companies use them to this day. Recognizing the sophistication of the technology, the Food and Drug Administration (FDA) has since designated the wheat kit as the official testing method for gluten-free foods.
Morinaga Institute of Biological Science, Inc.
External Presentation of
Morinaga presents its daily research findings at a wide variety of locations.
Here, we introduce several research paper results published in academic journals and printed materials.
- Biological and Pharmaceutical Bulletin 2013, 36(10) 1577-1582
- Comparison of (?)-Epigallocatechin-3-O-gallate (EGCg) and O-Methyl EGCG Bioavailability in Rats
- Bioscience, Biotechnology, and Biochemistry 2013, 77(8), 1792-4.
- Oxidative Stress during Development of Alcoholic Fatty Liver: Therapeutic Potential of Cacao Polyphenol
- May 2013 ACS Symposium series, "Tropical and Subtropical Fruits: Flavors, Color, and Health Benefits"
- Seeking a New Anti-Skin-Aging Material: Piceatannol and Its Derivatives from Passion Fruit (Passiflora edulis) Seed
- Biological and Pharmaceutical Bulletin 2013, 36(5) 845-849
- The Protective Effects of Piceatannol from Passion Fruit (Passiflora edulis) Seeds in UVB-Irradiated Keratinocytes
- Food and Function 2013, 4(2), 249-257
- Hydroxylation of (-)-epigallocatechin-3-O-gallate at 3”, but not 4”, is essential for the PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase in endothelial cells and relaxation of coronary artery rings
- Biochemical Biophysical Research Communications 2013, 430, 1164-1168
- Effect of long-term piceatannol treatment on eNOS levels in cultured endothelial cells
- The Journal of Neuroscience 2012, 32(39), 13470-13487
- Capsaicin Induces Theta-Band Synchronization between Gustatory and Autonomic Insular Cortices
- April 2012 Cocoa Butter and Related Compounds
- Morphology of Chocolate Fat Bloom
- Neuroscience 2012, 218, 326-34
- Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation.
- Journal of Agricultural and Food Chemistry 2011, 59(11), 6209-6213
- Identification of the Strong VasorelaxingSubstance Scirpusin B, a Dimer of Piceatannol, from Passion Fruit (Passiflora edulis) Seeds
- Analytical Sciences 2011, 27, 1257-1260
- An Abnormal Temperature Dependence of Alkylpyrazines' Retention in Reversed-Phase Liquid Chromatography
- Journal of Nutritional Science and Vitaminology 2011, 57(3), 246-250
- Effects of Citrulline Supplementation on Fatigue and Exercise Performance in Mice.
- Journal of Agricultural and Food Chemistry 2010, 58 (20), 11112-11118
- Extract of Passion Fruit (Passiflora edulis) Seed Containing High Amounts of Piceatannol Inhibits Melanogenesis and Promotes Collagen Synthesis
- Journal of the American Oil Chemists' Society 2010, 87(1), 19-27
- Bloom Formation on Poorly-Tempered Chocolate and Effects of Seed Addition
- Journal of Agricultural and Food Chemistry 2010, 58(3), 1903-1908
- Antihypertensive Effect of Benifuuki Tea Containing O-methylated EGCG
- J. Oral Biosci 2010, 52(3), 283-291
- Antibacterial Effects of Cocoa on Periodontal Pathogenic Bacteria
International Institution Presentations
- June 6-7,2013 7th World Congress on Polyphenols Applications (Bonn)
- BIOAVAILABILITY OF PICEATNNOL IN RATS: COMPARISON WITH RESVERATROL
- DISTRIBUTION AND CONTENT OF PICEATANNOL IN PASSION FRUIT (GENUS Passiflora)
- May 11-12,2013 13th International Conference of FFC (KYOTO)
- The potential benefits of piceatannol and passion fruit (Passiflora edulis) seed extract in blood vessels and blood flow
- Passion fruit seed extract and piceatannol suppress blood glucose levels in diabetic and obese model mice
- November 14-18,2012 The Society for free radical Biology and Medicine's 19th Annual Meeting (San Diego）
- The effect of Passion Fruit seeds extract that contains piceatannol
- Effect of Long-term Treatment of Piceatnnol on eNOS in Cultured endothelial Cell
- October 22-27,2012 KEYSTONE SYMPOSIA on Molecular and Cellular Biology -Aging and Diseases of Aging- (Tokyo)
- Piceatannol is more effective than resveratrol on eNOS up-regulation in the human endothelial cells
- July 28 - August 1,2012 2012 International Congress on Natural Products Research （New York City)
- HUMAN OSTEOSARCOMA PROLIFERATION INHIBITORS FROM ROYAL JELLY
- June 7-8,2012 6th World Congress on Polyphenols (Paris)
- PROTECTIVE EFFECTS OF PICEATANNOL FORM PASSION FRUIT(Passiflora edulis) SEEDS IN UVB-IRRADIATED KERATINOCYTES
- November 20-23,2011 2011 International Conference on Food Factors (Taipei)
- The anti-oxidative capacities and absorption rate of various methylated EGCG derivatives
- Isolation and Structure elucidation of Antioxidative Compounds from Chrysanthemum morifolium
- Synthesis and Biological activity of (-)-Epigallocatechin-3-O-gallate (EGCg) Derivatives.
- October 16-19,2011 Starch Round Table, America Association of Cereal Chemistry International Conference (California)
- New procedures for determination of the hydrophobicity of wheat starch granules
- December 13-17,2010 Neuroscience 2010 (San Diego)
- Electrophysiological properties of capsaicin-induced currents in layer II/III and layer V pyramidal cells of the insular cortex.